Baclofen (Lioresal); Skeletal Muscle Relaxant; Inj,
intrathecal (preservative free): 005 mg/mL [1 mL], 0.5 mg/mL [20 mL], 2 mg/mL [5 mL]
Tab: 10, 20 mg;
Spasticity (Oral):
2-7 yrs: 10-15 mg/day titrate dose q3days in increments of 5-15 mg/day (max 40 mg/day).
>8 yrs: Titrate dose as above to maximum of 60 mg/day.
Extemporaneous suspension can be prepared with 60-day stability under refrigeration.
Intrathecal:
Screening dose: 50 mcg
intrathecal x 1, observe for 4-8 hrs; if ineffective may try 75 mcg and then 100 mcg q24h.
If drug is effective, maintenance continuous infusions in the range of 100-300 mcg/day (children <12 yrs) and 300-800 mcg/day (>13 yrs) have been
used.