An isolated report describes baclofen toxicity
(confusion, disorientation, bradycardia, blurred vision, hypotension and hypothermia) in a patient who took ibuprofen
. It appeared that the toxicity
was caused by ibuprofen-induced acute renal
impairment leading to baclofen
The general importance of this interaction is likely to be very small. There appears to be no information about baclofen
and other NSAIDs, and little reason for avoiding concurrent use.