AZOLES AND TRIPTANS - ITRACONAZOLE OR KETOCONAZOLE

Ketoconazole raises the plasma levels of eletriptan 2.7-fold. Itraconazole is expected to interact similarly.
The manufacturer states that the concurrent use of ketoconazole and itraconazole with eletriptan should be avoided. The US manufacturers further recommend that eletriptan should not be given within 72 hours of these azoles. Other triptans would be expected to have little or no interaction with the azoles and may be suitable alternatives.
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