AZOLES AND SOLIFENACIN

Ketoconazole increases solifenacin levels 2- to 3-fold by inhibiting CYP3A4. The manufacturers predict that other CYP3A4 inhibitors (e.g. itraconazole) will have the same effect.
It is recommended that only 5 mg of solifenacin should be used in patients taking itraconazole or ketoconazole. The concurrent use of solifenacin and these azoles is contraindicated in patients with severe renal impairment or moderate hepatic impairment.
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