AZOLES AND PROTEASE INHIBITORS - PROTEASE INHIBITORS WITH ITRACONAZOLE

Itraconazole increases the levels of amprenavir, indinavir, lopinavir/ritonavir, and saquinavir, and may theoretically increase the levels of other protease inhibitors. Some
protease inhibitors, especially ritonavir and possibly indinavir, may increase itraconazole levels.
The manufacturers of indinavir advise modestly reducing the indinavir dose to 600 mg every 8 hours if it is to be given with itraconazole. Most manufacturers say that doses of itraconazole greater than 200 mg a day are not recommended with protease inhibitors. Be alert for itraconazole adverse effects (e.g. abdominal pain, dyspepsia).