AZOLES AND PHENYTOIN - ITRACONAZOLE OR KETOCONAZOLE

Phenytoin reduces itraconazole levels (by about 90%). Ketoconazole may interact similarly with phenytoin, and fosphenytoin, a prodrug of phenytoin, may interact similarly with these azoles.
Concurrent use of phenytoin and itraconazole (and probably ketoconazole) should be avoided unless the benefits are expected to outweigh the risks. It seems highly likely that these azoles will be ineffective.
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