Itraconazole levels may become undetectable if buffered
didanosine is taken at the same time. In one case this resulted in treatment failure. A similar interaction would be expected with
ketoconazole.
Itraconazole and
ketoconazole should be taken at least 2 hours before buffered
didanosine. Consider changing to enteric-coated
didanosine as it does not appear
to affect absorption of these
azoles.