Although some pharmacokinetic interactions occur between the azoles and macro- lides, most do not appear to be of clinical significance. However, clarithromycin appears to almost double itraconazole levels, and ketoconazole may almost double telithromycin levels. Monitor the effects of concurrent use of these azoles with clarithromycin or telithromycin. Consider either reducing the dose of the affected drug if adverse effects occur or using a different combination.
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