Ketoconazole increases the AUC of
cilostazol by more than 2-fold. Itraconazole is predicted to interact similarly. Fluconazole and miconazole may also interact, but probably to a lesser extent.
The US manufacturers suggest halving the dose of
cilostazol in the presence of
itraconazole or
ketoconazole. However, the UK manufacturers contraindicate the concurrent use of CYP3A4 inhibitors (which could be taken to
mean all of the azoles).