Voriconazole increases the AUC of
ciclosporin in stable
renal transplant patients by between about 1.7- and 2.5-fold.
The dose of
ciclosporin should be halved when initiating
voriconazole, and
ciclosporin levels should be carefully monitored during treatment. The
ciclosporin dose should be increased again when
voriconazole is withdrawn.