Itraconazole (and therefore probably ketoconazole) can markedly raise the
serum levels of
felodipine (by up to about 8-fold), which increases its adverse effects, in particular ankle and leg swelling. Ketoconazole raises the levels of
lercanidipine and
nisoldipine (peak
plasma levels increased by roughly 10-fold).
Concurrent use is contraindicated.