AZOLES AND BENZODIAZEPINES - OTHER BENZODIAZEPINES

The effects of the benzodiazepines may be increased and prolonged by azole antifungals. Moderate interactions have been seen between alprazolam and itracona- zole or ketoconazole, brotizolam and itraconazole, or zolpidem and ketoconazole.
The deepness of sleep and its duration may be increased. Monitor the outcome of concurrent use and consider decreasing the benzodiazepine or zolpidem dose.