AZATHIOPRINE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

Azathioprine appears to increase warfarin requirements, and cases of bleeding have occurred when azathioprine is stopped. Dose increases of up to 4-fold have been needed. Mercaptopurine appears to interact similarly with acenocoumarol.
Monitor the anticoagulant effect if azathioprine or mercaptopurine is added or
withdrawn and adjust the warfarin dose as necessary. Similar precautions would
seem necessary with any coumarin.
(16)
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