ATOVAQUONE AND RIFABUTIN

In one study the concurrent use of atovaquone and rifabutin resulted in a 34% decrease in the AUC of atovaquone and a small 19% decrease in rifabutin levels.
It has been suggested that no atovaquone dosage adjustment is needed. However, in the UK, the manufacturer of atovaquone still considers that rifabutin use could result in subtherapeutic atovaquone levels and so they advise against the use of this combination.
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