ASPIRIN AND PROBENECID

The uricosuric effects of high doses of aspirin or other salicylates and probenecid are paradoxically mutually antagonistic.
Regular dosing with substantial amounts of salicylates should be avoided, but small very occasional analgesic doses probably do not matter. Serum salicylate levels of 50 to 100 mg/L are necessary before this interaction occurs. Antiplatelet- dose aspirin seems unlikely to interact.
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