The uricosuric effects of high doses of
aspirin or other salicylates and
probenecid are paradoxically mutually antagonistic.
Regular dosing with substantial amounts of salicylates should be avoided, but small very occasional analgesic doses probably do not matter.
Serum salicylate levels of 50 to 100 mg/L are necessary before this interaction occurs. Antiplatelet- dose
aspirin seems unlikely to interact.