ASPIRIN AND DIURETICS - LOOP DIURETICS

Aspirin may reduce the diuretic effect of bumetanide, furosemide, and piretanide, and the combination of aspirin and furosemide may increase the risk of acute renal failure and salicylate toxicity. The risk of ototoxicity with high doses of salicylates may theoretically be increased by loop diuretics.
The clinical significance of this interaction is unclear. However, aspirin should be avoided in patients with recurrent hospital admissions for worsening heart failure. Be aware that renal impairment and otoxicity are a possibility in patients receiving high dose of salicylates, and consider increasing monitoring for these effects.
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