The manufacturers say that aprepitant should not be used with phenytoin as the levels of aprepitant and its efficacy are expected to be reduced. Phenytoin levels may also be reduced. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly. Avoid concurrent use. If both drugs are given monitor aprepitantefficacy and phenytoin levels carefully.
(16)
This site is intended for general information only. The information provided on this site does not constitute medical advice and should not be relied upon. You should not act or refrain from acting on any legal or medical matter based on the content of this site.