APREPITANT AND PHENYTOIN

The manufacturers say that aprepitant should not be used with phenytoin as the levels of aprepitant and its efficacy are expected to be reduced. Phenytoin levels may also be reduced. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly.
Avoid concurrent use. If both drugs are given monitor aprepitant efficacy and phenytoin levels carefully.
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