APREPITANT AND PHENOBARBITAL

Rifampicin, a potent inducer of CYP3A4, reduces the AUC of aprepitant (and probably its prodrug fosaprepitant) by 91%; reduced efficacy would be expected. Phenobarbital (and therefore probably primidone), another potent inducer of CYP3A4, is predicted to interact similarly.
The UK manufacturer recommends that concurrent use should be avoided.
(14)
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