The concurrent use of
aprepitant and
diltiazem appears to increase the levels of both drugs by almost 2-fold, although this did not result in any significant cardiovascular
effects. Fosaprepitant, a prodrug of
aprepitant, would be expected to interact similarly.
The
clinical relevance of this interaction is uncertain, however the lowest dose of
aprepitant may be appropriate. Be alert for the adverse effects of both drugs.