APREPITANT AND CALCIUM-CHANNEL BLOCKERS

The concurrent use of aprepitant and diltiazem appears to increase the levels of both drugs by almost 2-fold, although this did not result in any significant cardiovascular
effects. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly.
The clinical relevance of this interaction is uncertain, however the lowest dose of aprepitant may be appropriate. Be alert for the adverse effects of both drugs.
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