Venlafaxine can almost double haloperidol levels. Adverse effects resulting from this interaction have been seen in practice. A retrospective study found that venlafaxine caused a 27% increase in olanzapine levels. The concurrent use of aripiprazole with venlafaxine has led to adverse effects such as the neuroleptic malignant syndrome and extrapyramidal symptoms.
Monitor the outcome closely, being alert for the need to reduce the haloperidol dosage. The clinical significance of the raised olanzapine levels is unclear. Be awareof the possibility of an interaction between aripiprazole and venlafaxine if adverse effects become troublesome.
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