Pimozide levels are expected to be increased by fluoxetine,
fluvoxamine,
paroxetine, or sertraline. The use of
SSRIs and
pimozide has also led to extrapyramidal adverse effects, oculogyric crises and sedation in rare cases.
Raised
pimozide levels can cause torsade de pointes arrhythmias, which can be fatal. The manufacturers of
pimozide contraindicate its use with
SSRIs.