Rifampicin is predicted to decrease aripiprazole and quetiapine levels. An isolated report describes a marked fall in the serum levels of a patient taking clozapine when he was given rifampicin. Haloperidol levels appear to be decreased by rifampicin.
Be alert for the need to use an increased dosage of these antipsychotics in the presence of rifampicin. The manufacturers recommend that the dose of aripiprazole should be doubled.
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