ANTIPSYCHOTICS AND PROTEASE INHIBITORS - QUETIAPINE

Quetiapine levels are increased 6-fold by ketoconazole, a potent inhibitor of CYP3A4. Protease inhibitors are also inhibitors of CYP3A4 and are therefore predicted to interact similarly.
Monitor for signs of adverse antipsychotic effects if a protease inhibitor is also given, and consider reducing the dose as necessary.
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