levels, and possibly clozapine
levels, are roughly halved by phenobarbital
. Aripiprazole, chlorpromazine
and possibly thioridazine levels are also reduced by phenobarbital
. The plasma
levels of quetiapine are predicted to be reduced by barbiturates.
Monitor concurrent use to ensure that the antipsychotics
remain effective. The manufacturers of aripiprazole
suggest doubling its dose. It is also important to consider the seizure potential when prescribing antipsychotic medications.