ANTIPSYCHOTICS AND MACROLIDES - SERIOUS INTERACTIONS

Clarithromycin can increase the levels of pimozide, which is believed to increase its serious cardiotoxicity. The manufacturers predict that other macrolides will interact similarly, but note that not all macrolides would be expected to interact, see macrolides. Erythromycin slightly raises the levels of sertindole, and concurrent use increases the incidence of adverse effects (diarrhoea, abdominal pain, dizziness) but no ECG changes appear to occur.
The concurrent use of macrolides is contraindicated with pimozide and sertindole because of the risks of QT interval prolongation. Consider also drugs that prolong the QT interval.
(21)
© 2006-2021 medpill.info Last Updated On: 10/20/2021 (0)
×
Wait 20 seconds...!!!