Clarithromycin can increase the levels of pimozide
, which is believed to increase its serious cardiotoxicity. The manufacturers predict that other macrolides
will interact similarly, but note that not all macrolides
would be expected to interact, see macrolides
. Erythromycin slightly raises the levels of sertindole, and concurrent use increases the incidence
of adverse effects (diarrhoea, abdominal pain, dizziness) but no ECG changes appear to occur.
The concurrent use of macrolides
is contraindicated with pimozide
and sertindole because of the risks of QT interval prolongation. Consider also drugs that prolong the QT interval.