ANTIPSYCHOTICS AND GUANETHIDINE

Large doses of chlorpromazine may reduce or even abolish the antihypertensive effects of guanethidine. The antihypertensive effects of guanethidine can be reduced by haloperidol and thiothixene. However, in some patients the hypotensive effect of chlorpromazine may predominate. Note also, that the antipsychotics can cause postural hypotension.
Increases or decreases in blood pressure may occur as a result of concurrent use. Monitor blood pressure adjusting the guanethidine dose as necessary.
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