Bupropion is predicted to inhibit the metabolism of haloperidol, risperidone, and thioridazine.
The manufacturers recommend that if any of these drugs are added to treatment with bupropion, they should be given in doses at the lower end of the range. If bupropion is added to existing treatment, decreased dosages of the antipsychotics should be considered. However, there appear to be no reports of problems with the concurrent use of any of these drugs. Note that both bupropion and antipsychotics can lower the seizure threshold. A maximum dose of 150 mg of bupropion should be considered for patients prescribed other drugs that may lower the convulsive threshold.
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