Bupropion is predicted to inhibit the
metabolism of
haloperidol,
risperidone, and thioridazine.
The manufacturers recommend that if any of these drugs are added to treatment with bupropion, they should be given in doses at the lower end of the range. If
bupropion is added to existing treatment, decreased dosages of the
antipsychotics should be considered. However, there appear to be no reports of problems with the concurrent use of any of these drugs. Note that both
bupropion and
antipsychotics can lower the seizure threshold. A maximum dose of 150 mg of
bupropion should be considered for patients prescribed other drugs that may lower the convulsive threshold.