Additive sedative effects would be expected when antipsychotics
are given with benzodiazepines
. Concurrent use has resulted in severe hypotension, respiratory depression
and, in rare cases, the neuroleptic malignant syndrome
. Rarely, fatal
hypotension and respiratory arrest have been reported when clozapine
was given with benzodiazepines
Be aware of these potential adverse effects, but note that concurrent use is common and most often uneventful.