ANTIPSYCHOTICS AND BENZODIAZEPINES - ANTIPSYCHOTICS, GENERAL

Additive sedative effects would be expected when antipsychotics are given with benzodiazepines. Concurrent use has resulted in severe hypotension, respiratory depression and, in rare cases, the neuroleptic malignant syndrome. Rarely, fatal
hypotension and respiratory arrest have been reported when clozapine was given with benzodiazepines.
Be aware of these potential adverse effects, but note that concurrent use is common and most often uneventful.
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