Additive sedative effects would be expected when
antipsychotics are given with
benzodiazepines. Concurrent use has resulted in severe hypotension, respiratory
depression and, in rare cases, the neuroleptic malignant
syndrome. Rarely, fatal
hypotension and respiratory arrest have been reported when
clozapine was given with
benzodiazepines.
Be aware of these potential adverse effects, but note that concurrent use is common and most often uneventful.