ANTIPSYCHOTICS AND APREPITANT

Aprepitant inhibits the enzymes involved in the metabolism of pimozide, and is therefore expected to raise pimozide levels, which may result in potentially fatal torsade de pointes arrhythmias. Fosaprepitant, a prodrug of aprepitant, would be expected to interact similarly.
Concurrent use is contraindicated. Caution is needed in the 2 weeks after aprepitant is stopped as there may be some residual enzyme inhibiting activity.
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