inhibits the enzymes involved in the metabolism
, and is therefore expected to raise pimozide
levels, which may result in potentially fatal torsade de pointes arrhythmias. Fosaprepitant, a prodrug of aprepitant
, would be expected to interact similarly.
Concurrent use is contraindicated. Caution is needed in the 2 weeks after aprepitant
is stopped as there may be some residual enzyme