Centrally-acting dopamine antagonists (such as the antipsychotics, including
prochlorperazine used at an antiemetic dose) may antagonise the effects of
apomorphine. However, note that
clozapine may be used to reduce the
symptoms of neuropsychiatric complications of Parkinson's disease. Additive hypotensive effects are also possible, see
antihypertensives.
Concurrent use should be avoided, or monitored closely to ensure
apomorphine remains effective. Note that
prochlorperazine has been used safely in patients taking
apomorphine for erectile dysfunction.