Centrally-acting dopamine antagonists (such as the antipsychotics, including
prochlorperazine used at an antiemetic dose) may antagonise the effects of apomorphine. However, note that clozapine may be used to reduce the symptoms of neuropsychiatric complications of Parkinson's disease. Additive hypotensive effects are also possible, see antihypertensives.
Concurrent use should be avoided, or monitored closely to ensure apomorphine remains effective. Note that prochlorperazine has been used safely in patients taking apomorphine for erectile dysfunction.
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