The concurrent use of clozapine
can be effective and well tolerated but isolated reports describe a rise in serum clozapine
levels when risperidone
was added, and another describes the development of atrial ectopics. Dystonia has been seen when clozapine
was replaced by risperidone
The raised clozapine
levels and other adverse reactions seem to be isolated cases and therefore of doubtful general significance.