The concurrent use of
clozapine and
risperidone can be effective and well tolerated but isolated reports describe a rise in
serum clozapine levels when
risperidone was added, and another describes the development of atrial ectopics. Dystonia has been seen when
clozapine was replaced by
risperidone.
The raised
clozapine levels and other adverse reactions seem to be isolated cases and therefore of doubtful general significance.