Several patients have developed delirium when given fluoxetine,
paroxetine or sertraline with benzatropine, in the presence of
perphenazine or
haloperidol. Concurrent use in other patients has been uneventful.
The general
clinical importance of this interaction is uncertain, but be alert for evidence of confusion and possible delirium in patients given
SSRIs with benzatropine, particularly if they are also taking other drugs with antimuscarinic actions.