Several patients have developed delirium when given fluoxetine, paroxetine or sertraline with benzatropine, in the presence of perphenazine or haloperidol. Concurrent use in other patients has been uneventful.
The general clinical importance of this interaction is uncertain, but be alert for evidence of confusion and possible delirium in patients given SSRIs with benzatropine, particularly if they are also taking other drugs with antimuscarinic actions.
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