Several patients have developed delirium when given fluoxetine, paroxetine
or sertraline with benzatropine, in the presence of perphenazine
. Concurrent use in other patients has been uneventful.
The general clinical
importance of this interaction is uncertain, but be alert for evidence of confusion and possible delirium in patients given SSRIs
with benzatropine, particularly if they are also taking other drugs with antimuscarinic actions.