ANTIMUSCARINICS AND NITRATES

Drugs with antimuscarinic effects, such as the tricyclic antidepressants and disopyramide, depress salivation and many patients complain of having a dry mouth. In theory sublingual glyceryl trinitrate (nitroglycerin) tablets will dissolve less readily under the tongue in these patients, thereby reducing their absorption and effects. However, no formal studies seem to have been done to confirm that this actually happens.
A possible alternative is to use a glyceryl trinitrate (nitroglycerin) spray in patients who suffer from dry mouth.
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