ANTIHISTAMINES AND PROTEASE INHIBITORS - ASTEMIZOLE OR TERFENADINE

Nelfinavir markedly increases terfenadine levels, which is expected to increase the risk of QT prolongation and torsade de pointes arrhythmias. Other protease inhibitors are predicted to interact similarly with both terfenadine and astemizole.
Concurrent use is contraindicated.
(35)
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