Promethazine is a phenothiazine antihistamine. Rarely, cases of neuroleptic malig- nant
syndrome or extrapyramidal
symptoms have been seen when phenothiazines have been given with
MAOIs.
The UK manufacturer contraindicates the use of promethazine both with and for 14 days after stopping treatment with an MAOI, whereas the US manufacturer advises caution.