Isolated reports describe delayed hallucinations in a patient taking phenelzine and cyproheptadine, and the rapid re-emergence of
depression when
cyproheptadine was given to two other patients taking brofaromine or phenelzine.
It would be prudent to monitor for a reduction in
efficacy or an adverse response if
cyproheptadine is given with any MAOI or RIMA. The manufacturer of
cyproheptadine contraindicates concurrent use with
MAOIs, however, there appears to be no reason why
cyproheptadine cannot be used to treat
serotonin syndrome occurring in a patient taking an MAOI.