One study reported an increased incidence
of adverse effects when repaglinide
was given with simvastatin
, and there is a possibility of increased liver and muscle effects when pioglitazone or rosiglitazone are used with atorvastatin.
As yet there is insufficient evidence to recommend special precautions when the statins
are used with any antidiabetic drug. No clinically relevant adverse interactions appear to have been reported between statins
and sulphonylureas. The use of statins
in patients with diabetes
is known to be beneficial for both primary and secondary prevention of cardiovascular events.