One study reported an increased incidence of adverse effects when repaglinide was given with simvastatin, and there is a possibility of increased liver and muscle effects when pioglitazone or rosiglitazone are used with atorvastatin.
As yet there is insufficient evidence to recommend special precautions when the statins are used with any antidiabetic drug. No clinically relevant adverse interactions appear to have been reported between statins and sulphonylureas. The use of statins in patients with diabetes is known to be beneficial for both primary and secondary prevention of cardiovascular events.
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