One study reported an increased
incidence of adverse effects when
repaglinide was given with
simvastatin, and there is a possibility of increased liver and muscle effects when pioglitazone or rosiglitazone are used with atorvastatin.
As yet there is insufficient evidence to recommend special precautions when the
statins are used with any antidiabetic drug. No clinically relevant adverse interactions appear to have been reported between
statins and sulphonylureas. The use of
statins in patients with
diabetes is known to be beneficial for both primary and secondary prevention of cardiovascular events.