A Hypoglycaemia has occurred in patients with diabetes
when they were given
fluoxetine or sertraline, and a loss of hypoglycaemic awareness has also been reported with fluoxetine. Conversely, two isolated reports describe hyperglycaemia in patients given fluvoxamine
There would seem to be little reason for avoiding concurrent use of fluoxetine, fluvoxamine
or sertraline with sulphonylureas, but the cautious may want to increase blood glucose monitoring. The manufacturers of the SSRIs
warn that dosages of insulin or oral antidiabetics
may need adjustment during concurrent use, but the available evidence suggests that this is rare.