ANTIDIABETICS AND OCTREOTIDE

Octreotide decreases insulin resistance so that the dosage of insulin used by diabetics can be reduced. Octreotide appears to have no benefits in those with intact insulin reserves (type 2 diabetes). In addition, octreotide has been reported to reduce sulphonylurea-induced hypoglycaemia.
If octreotide is used, anticipate the need to reduce the insulin dosage (studies suggest by up to 50%). Octreotide may affect insulin secretion, and therefore glucose tolerance, and so it would certainly be prudent to monitor the effects of giving octreotide with any of the oral antidiabetics.
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