ANTIDIABETICS AND NSAIDS - AZAPROPAZONE OR PHENYLBUTAZONE

Although in general NSAIDs do not appear to interact with antidiabetics (see below) azapropazone and particularly phenylbutazone seem to cause a consistent lowering of blood glucose levels (probably by inhibiting the metabolism of the sulphonylureas), which has resulted in severe hypoglycaemia in a number of cases.
Concurrent use with phenylbutazone should be well monitored and a reduction in the dosage of the sulphonylurea may be necessary to avoid excessive hypoglycae- mia. The manufacturers of azapropazone say that the concurrent use of sulphonylureas is not recommended.
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