ANTIDIABETICS AND MACROLIDES - SULPHONYLUREAS

Isolated cases of hypoglycaemia have been described in patients taking glibenclamide (glyburide) or glipizide with clarithromycin or erythromycin. A study in healthy subjects found that hypoglycaemia may occur if tolbutamide is given with clarithromycin.
The general importance of these isolated cases is uncertain, but some caution may be warranted on concurrent use.
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