Cimetidine and ranitidine generally cause no clinically important changes in the
pharmacokinetics or pharmacodynamics of the sulphonylureas, although isolated cases of raised sulphonylurea levels and hypoglycaemia have been seen.
The evidence suggests that most diabetics do not experience any marked changes in their diabetic
control if they are given
cimetidine. However, a warning that
cimetidine may rarely and unpredictably cause hypoglycaemia may be helpful when
cimetidine is first started.