ANTIDIABETICS AND H2-RECEPTOR ANTAGONISTS - SULPHONYLUREAS

Cimetidine and ranitidine generally cause no clinically important changes in the pharmacokinetics or pharmacodynamics of the sulphonylureas, although isolated cases of raised sulphonylurea levels and hypoglycaemia have been seen.
The evidence suggests that most diabetics do not experience any marked changes in their diabetic control if they are given cimetidine. However, a warning that cimetidine may rarely and unpredictably cause hypoglycaemia may be helpful when cimetidine is first started.
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