ANTIDIABETICS AND FIBRATES - SULPHONYLUREAS OR INSULIN

The effects of the sulphonylureas can be enhanced by clofibrate in some patients, and a reduction in the dosage of the antidiabetics may be necessary. Hypoglycaemia has been reported with bezafibrate, ciprofibrate, fenofibrate and gemfibrozil in patients receiving sulphonylureas. Gemfibrozil has both increased and decreased the dosage requirements of insulin and various sulfonylurea antidiabetics.
There would seem to be no good reason for avoiding the concurrent use of sulphonylureas and fibrates, but be aware that the dosage of the antidiabetic may need adjustment. Patients should be warned that excessive hypoglycaemia occurs occasionally and unpredictably.
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