Occasionally and unpredictably acute hypoglycaemia has occurred in patients given various sulfonylureas and co-trimoxazole, although pharmacokinetic studies have not established an interaction. In high doses, co-trimoxazole alone may rarely cause hypoglycaemia. See also trimethoprim, for its effects on repaglinide and rosiglitazone.
The general importance of this interaction is uncertain. It may be prudent to increase blood glucose monitoring in diabetics taking high-dose co-trimoxazole.
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