ANTIDIABETICS AND AZOLES - MICONAZOLE

Hypoglycaemia has been seen in a few diabetics taking tolbutamide, glibenclamide (glyburide) or gliclazide when they were given miconazole.
Concurrent use should be monitored and the dosage of the sulphonylurea reduced if necessary. Warn patients to report any unexpected changes in blood glucose levels.
Posaconazole
Posaconazole slightly enhanced the blood glucose lowering effects of glipizide in healthy subjects, but did not affect single-dose tolbutamide metabolism.
No action is normally needed but warn patients to report any unexpected changes in blood glucose levels.
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