Hypoglycaemia has been seen in a few diabetics taking tolbutamide
, glibenclamide (glyburide
) or gliclazide when they were given miconazole
Concurrent use should be monitored and the dosage of the sulphonylurea reduced if necessary. Warn patients to report any unexpected changes in blood glucose levels.
Posaconazole slightly enhanced the blood glucose lowering effects of glipizide
in healthy subjects, but did not affect single-dose tolbutamide metabolism
No action is normally needed but warn patients to report any unexpected changes in blood glucose levels.