increases the blood glucose lowering effects of tolbutamide
in healthy subjects and possibly increases the effects of rosiglitazone and pioglitazone.
is added to tolbutamide
, patients should be warned to be alert for any evidence of increased hypoglycaemia; adjust the tolbutamide
dose as necessary. It may be prudent to increase the frequency of blood glucose monitoring if ketoconazole
is given with rosiglitazone or pioglitazone.