A Aluminium/magnesium hydroxide slightly reduces the absorption of strontium
ranelate (AUC decreased by 20 to 25%) if given with or 2 hours before strontium, but not when given 2 hours after strontium
. Calcium reduces the bioavailability of strontium
ranelate by about 60 to 70%. Antacids
should be taken 2 hours after strontium
ranelate. However, because it is also recommended that strontium
ranelate is taken at bedtime, the manufacturers say that if this dosing interval is impractical, concurrent intake is acceptable. For calcium preparations administration
should be separated by 2 hours.