A Aluminium/magnesium hydroxide slightly reduces the absorption of strontium
ranelate (AUC decreased by 20 to 25%) if given with or 2 hours before strontium, but not when given 2 hours after strontium. Calcium reduces the bioavailability of strontium ranelate by about 60 to 70%.
Antacids should be taken 2 hours after strontium ranelate. However, because it is also recommended that strontium ranelate is taken at bedtime, the manufacturers say that if this dosing interval is impractical, concurrent intake is acceptable. For calcium preparations administration should be separated by 2 hours.
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