ANTACIDS AND PROTEASE INHIBITORS

Drugs that increase gastric pH are predicted to reduce the plasma levels of atazanavir, and possibly also amprenavir. Tipranavir levels are decreased by up to 30% by antacids (containing aluminium/magnesium hydroxide).
The manufacturers of atazanavir recommend that it should be given 2 hours before or one hour after buffered medicinal products. This would include didanosine buffered tablets and antacids. The manufacturer of amprenavir recommends that it should not be given within one hour of antacids, and the manufacturer of tipranavir recommends that it should not be given within 2 hours of antacids.
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