Some, but not all studies have shown that antacids (containing aluminium, calcium or magnesium) do not usually interact to a clinically relevant extent with phenytoin. However, in some instances antacids have reduced phenytoin serum levels and this may have been responsible for some loss of seizure control in a few patients.
Concurrent use need not be avoided but if there is any hint that an epileptic patient is being affected by this interaction, separating the dosages by 2 to 3 hours may minimise the effects.
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