ANTACIDS AND PENICILLAMINE

The absorption of penicillamine can be reduced by 30 to 40% if antacids containing aluminium/magnesium hydroxide are taken concurrently.
For maximal absorption separate administration. A separation of 2 to 3 hours is usually sufficient with other similar interactions. Note that sodium bicarbonate does not appear to interact to a clinically significant extent.
(14)
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